Lentivirus


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Lentivirus

Lentivirus is a genus of retroviruses that cause chronic and deadly diseases characterized by long incubation periods, in the human and other mammalian species. Lentiviruses are RNA viruses that belong to the family Retroviridae. They contain the reverse transcriptase enzyme that converts RNA into DNA before becoming integrated into the genome of the host.


Lentiviral vectors are a preferred platform for anti-HIV gene therapeutics, due to their ability to pass through the nuclear envelope into cell nucleus thereby allowing transduction of nondividing cells and to maintain long-term and sustained expression of the genes carried by the vector.